PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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15-Aminopentadecanoic acid
0 ImagesCat. No.: HY-W401143CAS No.: 17437-21-715-Aminopentadecanoic Acid can be used as a PROTAC linker in the synthesis of PROTACs. 15-Aminopentadecanoic Acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
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Fmoc-Gly-Gly-Gly-NH-PEG4-C2-COOH
0 ImagesCat. No.: HY-160069CAS No.: 2922060-48-6
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L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride
0 ImagesCat. No.: HY-140346ASCAS No.: 2483829-89-4L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is the 13C- and 15N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Methyl 11-aminoundecanoate hydrochloride
0 ImagesCat. No.: HY-W088474CAS No.: 29833-32-7
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Tert-butyl 4-(2-prop-2-ynoxyethyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W674400CAS No.: 206862-65-9
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1-(2-(But-3-yn-1-yloxy)ethoxy)-6-chlorohexane
0 ImagesCat. No.: HY-201121CAS No.: 2896761-21-8
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Ph-PEG9-NH2
0 ImagesCat. No.: HY-W190821CAS No.: 868594-50-7
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Methyl 4-(((tert-butoxycarbonyl)amino)methyl)benzoate
0 ImagesCat. No.: HY-W102024CAS No.: 120157-96-2
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NHBoc-PEG4-methyl acetate
0 ImagesCat. No.: HY-W909956CAS No.: 1820674-09-6
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ethyl 3-(piperidin-4-yl)propanoate
0 ImagesCat. No.: HY-W151238CAS No.: 71879-55-5
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HS-PEG6-CH2CH2-Boc
0 ImagesCat. No.: HY-130881CAS No.: 1818294-40-4
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(S,R,S)-AHPC-PEG4-tosyl
0 ImagesCat. No.: HY-W800652CAS No.: 2839806-91-4
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4-Chloro-1-butyne
0 ImagesCat. No.: HY-W094977CAS No.: 51908-64-6Synonyms: 4-Chlorobut-1-yne
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4,4'-(Propane-1,3-diylbis(oxy))dianiline
0 ImagesCat. No.: HY-W342204CAS No.: 52980-20-8
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Tert-Butyl 3-(3-iodopropyl)azetidine-1-carboxylate
0 ImagesCat. No.: HY-W685841CAS No.: 1381947-37-0
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Methyl 8-oxooctanoate
0 ImagesCat. No.: HY-W613614CAS No.: 3884-92-2
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Biotinamide-C3-PEG3-C-alkyne
0 ImagesCat. No.: HY-172296CAS No.: 1252785-15-1Biotinamide-C3-PEG3-C-alkyne is a biotin PEG reagent containing a PEG3 chain linked to a terminal azide.
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Piperidin-4-amine-C5-O-C1
0 ImagesCat. No.: HY-162949CAS No.: 1098625-76-3
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3-(Azetidin-3-yl)propan-1-ol
0 ImagesCat. No.: HY-W367856CAS No.: 1379377-40-8
